Solid-phase enrichment and analysis of electrophilic natural products

• Frank Wesche,
• Yue He and
• Helge B. Bode

Beilstein J. Org. Chem. 2017, 13, 405–409, doi:10.3762/bjoc.13.43

• -von-Laue-Strasse 15, D-60438 Frankfurt am Main, Germany 10.3762/bjoc.13.43 Abstract In search for new natural products, which may lead to the development of new drugs for all kind of applications, novel methods are needed. Here we describe the identification of electrophilic natural products in crude

• entomopathogenic Photorhabdus bacteria. Keywords: azides; click chemistry; enrichment; electrophilic natural products; epoxides; glidobactin; Photorhabdus; stilbenes; Introduction Microorganisms are a major source for novel natural products and the subsequent development of new drugs for all kinds of

• for the detection of electrophilic natural products using azide as the nucleophile. Indeed, we could detect epoxystilbene 1 and three glidobactins from different Photorhabdus strains and some of these compounds are produced in such low amounts that they are not detectable in standard crude extracts